• Amino acid substitution can lead to structural and functional changes of protein.
  • This structure database is a collection of protein pairs with single residue difference in PDB.
  • It provides annotations of function changes induced by residue substitution.
  • It also provides information of local and global conformational changes and other important features.

    Real case of Diphthine synthase

    A residue substitution in the loop region incurred obvious local structural change: